Duke University Press publishes approximately 120 books and over 50 journals annually, and also offers eight electronic collections and the world renowned Duke Mathematical Journal.

Books and journals in the humanities and social sciences are available through the e-Duke Journals Scholarly Collection and the e-Duke Books Scholarly Collection. The Euclid Prime Collection and Duke Mathematical Journal are available on the dedicated mathematics platform of Project Euclid, a joint venture of Duke University Press and Cornell University. In collaboration with the University of Edinburgh, Duke University Press also publish an open access collection, The Carlyle Letters Online, which provides insight into the Victorian cultural period through a collection of over 10,000 letters.